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The Causes of Diabetes
All in the genes?
Not really! Our genetic make-up plays an
important role and a certain set of genes can
make us more or less susceptible to
developing diabetes. However, even if your
genes do make it more likely that you will
develop the disease, it doesn't mean you will.
Several gene variants have been identified
as contributing to type 1 diabetes but only a
small proportion of people with those genes
go on to develop the disease - less than 10
per cent. It follows that environmental factors
are necessary to trigger the reaction which
destroys insulin producing cells.
Lifestyle and environment also play a huge
role in the development and severity of type 2
diabetes. Even individuals with susceptible
genes and many of those who have already
developed the disease don't have to live with it
for the rest of their lives.
|
The relative(s) with the particular type of diabetes |
Risk of type 1 diabetes |
Risk of type 2 diabetes |
Diabetic mother Diabetic father Both parents diabetic Diabetic brother or sister Diabetic non-identical twin Diabetic identical twin |
2% 8% Up to 30% 10% 15% 40% |
15% 15% 75% 10% 10% 90% |
Lifestyle and environmental factors
Lifestyle is incredibly important and can
significantly increase or decrease the risk of
developing the disease. Even if both parents
have diabetes, it doesn't necessarily mean
their children will develop it too.
Type 1 diabetes
It has been known for years that type 1
diabetes is triggered by something in the
person's environment. The conventional
theory is that a viral or another infection
might be the culprit, making the body attack
its own insulin producing cells by mistake.
There is, however, a more uncomfortable
theory - that cows' milk is the main trigger
and it has been increasingly accepted since it
was first suggested in the early 1990's.
If an individual has a certain combination of
genes, making them more susceptible to type
1 diabetes, the environmental trigger is the
key which opens the door to the disease. But
if the trigger is avoided, they may never
develop diabetes. The theory is as follows.
A baby with a susceptible genetic make-up
is exposed to cows' milk early in life, for
example through infant formula. At the same
time the baby's immune system might be
weakened by a virus infection. When milk
proteins reach the intestine, they are not fully
digested and broken down into individual
amino acids as they should be. (Amino acids
are the building blocks of proteins.) Instead,
they are only broken down into chains of
amino acids and these fragments may be
absorbed into the blood where the immune
system recognises them as foreign intruders
and attacks them.
Coincidentally, the structure of some of
these dairy fragments is identical to the
surface structure of the body's own insulin producing cells (ß-cells) in the pancreas and it
cannot distinguish between the two. As a
result, both pancreas ß-cells and milk protein
fragments are attacked and destroyed by
the immune system and the child
becomes diabetic.
The process of ß-cell destruction can be
fast and aggressive, when the disease
develops within a few months or, more often,
it can take as long as 10 years or more as the
cells are gradually destroyed. Type 1 diabetes
is irreversible as the cells cannot regenerate.
So what exactly are the milk proteins
responsible for this reaction? There are
three which will trigger this immune
system reaction:
1 Bovine serum albumin (BSA)
Human milk also contains albumin but it is
different in structure to cows' albumin. When
a foreign body is identified in the blood
stream the immune system reacts by
producing antibodies to fight it, so the
presence of particular antibodies is an
indicator that there is something in the blood
that shouldn't be. When scientists tested type
1 diabetics and healthy children for
antibodies against BSA, the results were
astonishing. All diabetic children had
antibody levels as much as seven times
higher than the healthy children. Other
studies have followed and all but one have
found that diabetic children have high levels
of BSA antibodies in their blood.
2 ß-casein
The structure of human ß-casein is similar to
ß-casein from cows' milk but about 30 per
cent is different, which is assumed to be the
reason why the immune system attacks it. As with BSA, there are structural similarities
between cows' milk ß-casein and the
molecules on the surface of the insulin
producing cells in the pancreas. It is this close
similarity that causes the immune system to
react and attack both the cows' ß-casein as
well as its own pancreas cells by mistake.
3 Cows' insulin
Cows' insulin is present in formula milk and
can trigger the formation of specific
antibodies. Research shows that the immune
system of babies given cows' milk formula as
early as three-months old, reacts strongly
against the cows' insulin and produces antiinsulin
antibodies. This results in the body's
immune cells attacking human insulin also.
An extensive study of children from 40 different
countries confirmed a link between diet and
type 1 diabetes. The study set out to examine
the relationship between dietary energy from
major food groups and the occurrence of the
disease. Meat and dairy foods significantly
increased the risk of type 1 diabetes whilst a
diet based on plant foods resulted in a much
reduced risk of this disease. The more
meat and milk in the diet, the higher was
the incidence of diabetes but the more
plant-based foods that were eaten, the
lower the occurrence.
In summary, an early exposure to cows'
milk (via infant formula) puts susceptible
children at high risk of developing type 1 diabetes. If a baby cannot be breastfed until at
least six months old, a much better option is
soya-based formula. It provides all the
essential nutrients without triggering an
immune reaction. More than 20 per cent of all
US babies have been brought up on soyabased
formulae for 40 years or more - that's
millions and millions of children - with no
adverse reactions.
Type 2 diabetes
Type 2 diabetes is closely linked with being
overweight or obese - in fact, obesity is the
main risk factor, particularly abdominal obesity
where the weight sits around your waist.
According to the latest statistics, almost a
quarter of adults in England (24 per cent of
men and 25 per cent of women) are classified
as obese. In addition, 42 per cent of men and
32 per cent of women classified as overweight.
The numbers of obese children are equally
startling - 17 per cent of boys and 15 per cent
of girls aged two to 15. With this rapidly rising
number of overweight people, the risk of
diabetes is ever-increasing.
An extensive, 21-year study involving over
25,000 adults found that diabetes is less
frequent among vegetarians and vegans.
Those on meat-free diets had a 45 per cent
lower risk of developing diabetes compared to
the population as a whole. Another long-term
piece of research followed the eating habits of
people for 17 years. It showed that eating just
one serving of meat per week significantly increases the risk of
diabetes. People following a low-meat diet had a 74 per cent increase in the risk of type 2 diabetes compared to vegetarians.
The big question is why? What makes animal products so damaging to health? The answer is simple - fat is the main culprit.
Several studies revealed that in people with insulin resistance (one of the main problems in type 2 diabetes) microscopic drops of fat accumulate in body cells and interfere with their ability to react to insulin correctly. Even though their bodies might produce enough insulin, the fat inside cells blocks the necessary reactions. Muscle cells normally store small amounts of fat as
an energy reserve but, as the research shows, in insulin-resistant people, fat can build up to levels 80 per cent higher than in
other, healthy people. Slim people are not exempt because it takes years for diabetes and other symptoms to develop.
But it doesn't end here. An abundance of fat in the bloodstream also turns off some of those genes that normally help the body to
burn fat! A high-fat diet, therefore, not only causes the body to accumulate fat in the muscle cells but also slows down its ability to
burn that fat. The result is an inability to respond to insulin.
This paradox can be explained by our evolutionary history. When food was scarce, the bodies of our ancestors developed special
mechanisms to store fat when they had the opportunity - it was vital for their survival. We live in a much different world now but our
bodies are still ready to store fat at any time if we provide it for them.
The common diet in many countries, including the UK, is high in fat, animal products and sugary foods and low in complex carbohydrates. Not only is this responsible for ever-increasing numbers of overweight or obese people but it also increases the risk of diabetes and cardiovascular disease.
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